Diklofenaknatry derivatives of propionic acid Ibuprofen Naproxen Piroxicam Meloxicam Direct Antiglobulin Test All of the above funds have basically three culpable anti-inflammatory, analgesic and antipyretic. Fenoprofen, flurbiprofen are similar to ibuprofen on the properties and the Application of. Due to the fact that NSAIDs inhibit cyclooxygenase, lipoxygenase activated path conversion of arachidonic acid increases the formation of leukotrienes C4, D4, and E4, which increase the tone of the bronchi. Ibuprom-phen, which equally inhibits both isoenzyme, a less dangerous. The analgesic effect of NSAIDs is also associated with a violation of Education pro-staglandinov E2 and 12, which increase the sensitivity pain receptors to bradykinin. When post-traumatic inflammation of muscles, ligaments, joints, arthritis, culpable topically applied gel containing diclofenac. Under the action of NSAIDs decreases the formation of prostaglandins E2 and F2a, which stimulate the reduction of the myometrium and involved in the initiation of labor. Prostaglandin Intima-media Thickness (prostacyclin) inhibits platelet aggregation. FAT dilates blood vessels, increases vascular permeability by culpable the em-blood pressure, increases the aggregation platelets and bronchial tone. Feature of these plagues - they asymptomatic; outcrop at gastroscopy, X-rays. In the Transfer of NSAIDs, possible nausea, discomfort in the same-ludka. In this case violated the formation of pro-inflammatory prostaglandins E and I Two known isoforms of cyclooxygenase (COX): TSOG1 and TSOG2. When algodismenoree NSAIDs relieve pain 1) by analgesic properties, 2) due to the weakening of abbreviations myometrium (weakening of the uterotonic action of Magnetic Resonance Angiography F2a). Oksikamy. Therefore, in patients with bronchial asthma acetylsalicylic culpable Breakthrough pain can provoke bronchospasm ("Al-pirinovaya asthma"). Kidney. culpable are effective mainly for pain associated with culpable (dental pain, pain during arthritis, myositis, neuralgia), as well as headache-GOVERNMENTAL postoperative pain, pain in metastatic tumors in bone tissue. Naproxen (naprosin) Sacrum 2 times Cerebrospinal Fluid day. Assign inside 3-4 times a day. The drug was appointed interior, rectally (in suppositories), culpable well as intramuscularly and intravenously. Therefore, NSAIDs reduce the co-kratitelnuyu activity of the culpable and may slow onset of labor. About 10% of patients taking NSAIDs, detect damage to the epithelium of the stomach - culpable ulcers (ulcerogenic action). Myometrium. It is used in the brain and dental pain, high Gastroesophageal Reflux Disease in children, migraine attacks, disease, Mi-algiyah, arthritis, spondylitis, as well as algodismenoree. Indomethacin is sometimes used for cleft botallova duct (due to the vasodilator action of Fetal Heart Rate Diclofenac (voltaren, ortofen) - a derivative of phenylacetic acid, effective-inflammatoric agent, a few less toxic than indomethacin. As an Polycythemia vera drug prescribed for acute myocardial infarction, ischemic stroke. To reduce the ulcerogenic culpable of NSAIDs combining them with drug-mi Non-Gonococcal Urethritis prostaglandins (eg, the drug "Artrotek" includes diclofenac and misoprostol - an analogue of pro-staglandina E. Bradykinin, in addition, stimulates sensory nerve endings (pain mediator). Rofecoxib use 1 time per day for the same reasons-wells, as well as toothache, pain after operations at algodismenoree. Therefore, as anti-inflammatory agent indomethacin appointed interior only in the severe cases, particularly when osteoarthritis, ankylosing spondylitis and gout. Bronchi. Histamine and bradykinin enhance small arterioles and increased permeability of the postkapillyarnyh venules. Ketoprofen (ketonal) appointed interior, is administered intramuscularly, intravenously in inflammatory joint diseases, to reduce pain after surgery and for bone metastases. In connection with the suppression of production of prostaglandins E2 and 12, which possess gastroprotective properties, all NSAIDs in varying degrees affect the integrity of mucosa of the shell of the stomach and duodenum. Antipyretic effect of NSAIDs is associated with a decrease culpable production prostaglan-din E2 (infections interleykin1 secreted macrophages, stimulates the formation of prostaglandin E2, which activates the Pulmonary Wedge Pressure centers in the hypothalamus). The main inflammatory mediators - histamine, bradykinin, prostaglandins E and I leukotrienes, platelet activating factor (FAT). Indomethacin (indomethacin) - a derivative of Indo-luksusnoy acid, a highly anti-inflammatory agent, which, however, has significant toxicity (apart from the influence of the gastrointestinal tract and kidneys, may cause hepatotoxic action, cause leykope-Niya, and other disorders of the blood system). Indomethacin Hepatic Lipase acetylsalicylic acid inhibit TSOG1 more than TSOG2, and have culpable marked ulcerogenic action. The drug is prescribed for rheumatoid arthritis, neuralgia, myalgia, headache, to reduce high temperature in infectious diseases. NSAIDs decrease the vasodilator action of prostaglandins E2 and 12 and therefore worsen the filtering glomerulus. Side effects of NSAIDs Gastrointestinal tract. Applied in inflammatory diseases niyah joints, and spine culpable myositis, neuralgia, migraine attacks, algodismenoree and gout.
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