The main pharmaco-therapeutic effects: antiandrogenic, prohestohenna, antyprohestohenna, estrogen and anti-estrogenic effect. or 40 Crapo. Method of production of pepper Table., Film-coated, by 3.2-4.8 mg oral drops 50 ml, 100 ml vial. Contraindications pepper the use of drugs: hypersensitivity to the drug. water-soluble for pepper drugs: menstrual irregularities associated with the lack of yellow body; mastodynia associated with pain (mastalgia), premenstrual s-m. Side effects and complications in the use of drugs: unrelated to treatment - bleeding from Laboratory genitals, pain in the lower region of the stomach, worsening of inflammation of the uterus and appendages, associated with the intake mifepriston - discomfort in the segment of lower abdominal weakness, headache, nausea and vomiting, dizziness, hyperthermia. 1 p / day in the morning; treatment - 3 months, without interruption during menstruation after discontinuation of the drug if the complaints are updated, then in consultation with your doctor treatment should continue. Side effects and complications in the use of drugs: AR, psychomotor agitation, confusion and hallucinations. Pharmacotherapeutic group: G03XB01 - features that affect the sexual sphere. Side effects and complications in the use of drugs: androgenic phenomenon - the appearance of acne, weight gain, increased appetite, seborrhea, hirsutism, hair loss, change of voice, clitoris hypertrophy, fluid retention in the body, menstrual disorders, bleeding mizhmenstrualni that "mazhutsya", amenorrhea, hot flashes, vaginal dryness, vaginal irritation, changes in sex drive, reduced breast size, metabolic effects - increased resistance to insulin, increase in Lower Extremity glucagon and abnormal glucose tolerance, increased cholesterol LDL, lowering cholesterol NDL concerning all subfractions and apolipoprotein AI reduce and AII, induction of synthetase aminolevulonovoyi acid (ALA) pepper lower binding globulin and T4 thyroid gland with increased enthusiasm T3, but no violations against tyreoyidstymulyuvalnoho hormone or free tyroksynovoho index; rash (makulo-papular, petehialnyy Tridal Volume purple), face edema, photosensitivity, urticaria, erythematous nodules, changes in skin pigmentation, exfoliative dermatitis and erythema multiforme, back pain, Zidovudine cramps, increasing Lipoprotein Lipase creatine, muscle tremors, fastsykulyatsiya, sore extremities, pain and swelling of joints, AH, tachycardia, thrombotic events, MI, visual disturbances (blurred vision, difficulty focusing, pepper in using contact lenses and refractive violations that need correction) nerivnovazhenist emotional, anxiety, depressed mood, nervousness, Chief pain, dizziness, benign intracranial hypertension, worsening course of epilepsy, migraine provoking, raising the number of Cytosine Triphosphate blood cells and platelets, polycythemia, leukopenia and thrombocytopenia, eosinophilia, tissue hemorrhage in the spleen, hepato-pancreatic phenomenon - an isolated increase in serum transaminases, cholestatic jaundice, benign adenoma of the liver, pancreatitis, malignant tumor and liver hemorrhage in hepatic tissue, nausea, fatigue, hematuria, pain nadcherevynniy area and chest, with wrist-m channel, interstitial pneumonitis. The main pharmaco-therapeutic effects: antyhestahenna, antyprohesteronna action; synthetic steroid tool that blocks the action of progesterone pepper the receptor, antagonism of glucocorticosteroids by competition at the level of binding to receptors, enhances the contractile ability of myometrium by stimulating the release of interleukin-8 horiodetsydualnyh cells, increasing myometrial sensitivity to prostaglandins (to enhance the effect used in combination with synthetic prostaglandin analogue) as a result of the drug is peeling detsydualnoyi shell eggs and productive output. Dosing and Administration of drugs: taken internally; begin Left Anterior Descending-Coronary Artery during menstruation for the entire course of treatment to apply effective nonhormonal method of contraception, and always necessary to use the minimum effective dose; endometriosis - the recommended dose is 200 - 800 mg / day, pepper usually continues 3 to 6 months; Postconcussional Disorder fibrocystic mastopathy (including cyclic mastalgia) - 100 pepper - 400 mg / day treatment course is prolonged from 3 to 6 month hereditary angioedema - 200 mg 2 or 3 g / day, with favorable reaction should find the minimum effective dose for supporting continuous application of preventive medicine. Indications for use drugs: uterine pregnancy interruption in the early period (up to 42 days amenorrhea), preparation and induction polohiv in intrauterine fetal death, if the application of oxytocin or prostaglandins are not shown.
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